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Brandt LJ, Feuerstadt P, Longstreth GF, Boley SJ

This is also the dose level where the conversation about whether to continue escalating or hold at the current dose becomes medically relevant

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Anti-obese effect in DIO mice model To evaluate the therapeutic effect of in vivo targeted knock-in of scExe4, we conducted a proof-of-concept study using diet-induced non-genetic obese (DIO) mice, which showed obesity and pre-diabetic symptoms through continuous high fat diet (HFD) feeding (Supplementary Fig